Yes, xGen UDI-UMI Adapters are available methylated as xGen Methyl UDI-UMI Adapters. Bisulfite conversion can be carried out after ligation, but before library amplification. It is important to note that strand-specific libraries constructed using xGen Methyl UDI-UMI Adapters have the insert strandedness flipped (i.e., to the opposite strand) compared to standard TruSeq™-Compatible Full-length Adapters. This strand flip must be accounted for during data analysis for strand-specific applications, such as Methyl-Seq.
TruSeq is a trademark of Illumina, Inc. and is used with permission.